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Matsuoka AJ, Morrissey ZD, Zhang C, et al

The key word is documented

To determine whether these transcriptomic changes were reflected at the metabolic level, we quantified -hydroxybutyrate, a terminal product of -oxidation, in both cell lysates and culture supernatants

When gastrointestinal symptoms occur, they often relate to supplement formulation, excipients, or underlying health conditions rather than the vitamin itself

An animal study showed that NAC increased histamine release in conjunction with fluoride.[ref] In people given IV n-acetylcysteine in a hospital setting for acetaminophen poisoning, about 8% of the patients had an anaphylactoid reaction, defined as cutaneous (urticaria, pruritus, angioedema) or systemic (hypotension, respiratory symptoms) within five hours of receiving the IV