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ALT-2074 (BXT-51072), a novel analog of ebselen, has completed Phase II clinical trials in the contexts of diabetes and coronary artery disease (NCT00491543)

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Regarding how iron overload and imbalance in ROS homeostasis affect, IE in patients with -thal, the current research suggests that iron overload leads to an imbalance in ROS homeostasis, which in turn causes oxidative damage to erythroid cells

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O (Outcome): Primary outcome: changes in serum Vitamin B12 levels, clinical improvement of Vitamin B12 deficiency symptoms