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If human trials with the compound show safety and efficacy, NNMT inhibitors like 5-amino-1MQ could serve to prevent and/or slow age-related muscle deterioration in humans, a tantalizing prospect
Heat, bugs, and surprises included
Arthritis Rheumatol (Hoboken NJ) (2015) 67(7):17519
LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al
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