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89 Additionally, the binding affinity between protein disulfide-isomerase (P4HB) and prostaglandin G/H synthase 2 (PTGS2) is enhanced by lactylation of P4HB at K311, subsequently leading to SH3-domain-containing GRB2-like protein B1 (SH3GLB1)-mediated mtROS accumulation and coiled-coil domain-containing protein 2 (NDP52)-induced mitophagy