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The SUSTAIN clinical trial programme has documented Semaglutides superior glycaemic and weight-reducing efficacy relative to placebo, sitagliptin, exenatide extended-release, insulin glargine, and dulaglutide establishing Semaglutide as the highest-efficacy selective GLP-1R agonist in comparative clinical pharmacology and providing the translational reference dataset for pre-clinical mechanistic research into the molecular basis of its superior outcomes

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This approach is consistent with clinical guidelines and helps reduce gastrointestinal side effects

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Ipamorelin is a selective ghrelin receptor agonist that enhances this effect by stimulating growth hormone release without elevating cortisol or prolactin