Also, a small cross-sectional study of 36 women with PCOS noted no changes in depression scores associated with liraglutide use over 6 months 204 , while another reported worsening depressive symptoms, which correlated with higher perceived stress scores, in 43 exenatide users with diabetes and obesity against non-users at 3 months 205
Subtype analysis showed robust evidence that GLP-1R expression in pancreas is associated with a reduced risk of ENOC
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Tang ST, Tang HQ, Su H, et al
Indeed, previous reports indicate that GLP-1R signaling is blunted when dynamin-dependent endocytosis is inhibited chemically 10 or genetically 56