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The clinical limitation is the half-life

Metabolomics 14:15 Campbell JM, Mahbub SB, Bertoldo MJ, Habibalahi A, Goss DM, Ledger WL, Gilchrist RB, Wu LE, Goldys EM (2022) Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes

doi: 10.1038/nature06639

Although TRPV6 is a key mediator of intestinal calcium absorption in humans, significant Ca + uptake still occurs in TRPV6 - / - mice, suggesting compensatory mechanisms via other channels or molecules ( + extrusion from IECs ( The functionality and calcium transport mechanism of IECs are intricately linked to Vitamin D (VitD), and a shortage in VitD has a considerable detrimental effect on bone health

FDA safety concerns The FDA includes DSIP on its list of bulk drug substances with potential safety risks