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These studies showed significant alterations in ceramide levels as well as benzoate, creatine and fatty acid metabolisms and sphingomyelins pathways, with respect to ALS progression 49 , and these changes in metabolite levels correlated with patients ALS Functional Rating Scale (ALSFRS-R) scores 55

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The number of genes in common with the analysis of any of the Atm inhibitors (AZD0156, KU55933) was 8 genes ( A3galt2, Acta1, Csrp1, Eif1a, Hspb8, Mki67, Tuba1c, and Tubb3 )

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For comparative context, GLP-pathway compounds such as GLP-3 RT and GLP-2 T are studied through an entirely different metabolic mechanism and are worth reviewing separately