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The gradual dose escalation schedule specifically aims to minimise side effects whilst building towards the therapeutic dose

The limitations of this study include the limited efficacy of TIR in mitigating DXN-induced mortality, weight loss, and oxidative stress, as well as the absence of histological validation for the neurological observations, particularly within the cortex and hippocampus

To correct for the partial-volume effect, fractions of CSF and brain tissue (gray and white matters) were determined within the voxel using FSL FAST segmentation

Rotate the belly button in four directions: top left, top right, bottom right, and bottom left

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