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placebo for 72 weeks, with a primary endpoint of improvement in fibrosis 1 stage without worsening of steatohepatitis.75 Two subsequent phase IIb trials are also underway in NASH patients with either cirrhosis and severe portal hypertension (HVPG 12 mmHg) or decompensated cirrhosis

But large, definitive trials designed specifically around alcohol use disorder are still in progress

Pain during injection is influenced by several factors, including the amount of fat in the area, the presence of nerve endings, and how deeply the needle is inserted

For the deepest dive into how retatrutide mechanisms differ from other options, the retatrutide versus Mounjaro comparison and the cagrilintide versus retatrutide analysis provide detailed mechanism-by-mechanism breakdowns

& Meyuhas, O