data.govt.nz cigarette smoking behaviour regional council Trends in and vaping: New Zealand Health Survey 2024/25 Tobacco Control Data Repository

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It has a short half-life, about 2 hours, which means most of a dose is gone in 8-10h

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Indeed, individuals with genetic polymorphisms in CYP2D6 were more likely to have participated in more antidepressant medication trials and also have been shown to switch among antidepressants more often (176, 177)