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GrimAge has been shown to outperform earlier epigenetic clocks in predicting mortality and disease risk, while DunedinPACE measures the rate of aging and has demonstrated strong associations with morbidity, disability, and mortality in longitudinal studies

In addition, the accumulation of copper can lead to oxidative damage to the mitochondrial membrane and ATP consumption

These examples highlight how the intestinal epithelium is continuously exposed to harmful chemicals present in the diet which can attenuate its efficacy in limiting the systemic entry of luminal components

Additional indicators related to digitalisation show among others a higher potential exposure of occupations in the tourism sector towards Artificial Intelligence (Felten et al., 2021) and a relatively high share of digital skills needed to conduct their usual tasks (Lennon et al., 2023), even though such exposures are rather moderate when compared to their computerisation potentials