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In a previous paper we have demonstrated MAHT at 8 mg induces a significant reduction in serum IgE and HLA-DR expression in PBMC, together with a modulation in CD3 + , CD4 + and CD8 + lymphocyte subpopulations (39)

When two or more independent drugs are combined, their effects add up, and the Bliss synergy score is 0 ( Figures 3D, E )

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