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(Osaka, Japan)

[13] A 2021 meta-analysis found that over 1 year of clinical use, tirzepatide was superior to dulaglutide, semaglutide, insulin degludec, and insulin glargine in improving blood sugar control and reducing body weight

The evolution from single to triple agonism The trajectory of incretin-based obesity pharmacotherapy shows a clear pattern of increasing complexity and efficacy: First generation (single agonist): Liraglutide (Saxenda) and semaglutide (Wegovy) target GLP-1 only

Given the many factors that come into play when deciding on the most appropriate choice of treatment for T2DM in an individual patient, in the context of GLP-1RAs, a clinical decision algorithm that incorporates author opinion is proposed

10.1016/j.bbrc.2021.08.080 16 CaoJ