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Antioxidant Defense Glutathione peroxidases use glutathione to reduce peroxides and limit oxidative damage to proteins, membranes and mitochondria

10.1042/bj2290353

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Accordingly, we encourage the adoption of GLP-1RA plus SGLT2i combination therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) or multiple risk factors for ASCVD (i.e., age 55 years, overweight/obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria)

The benefits of reduced PM 10 exposure were not equally distributed across the population but were modified by the individual genetic make-up determining oxidative stress defense 39