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Semaglutide starts GLP-1 receptors mainly in the hypothalamus, very the arcuate nucleus and paraventricular nucleus, regions crucial for regulating energy balance and food intake

Off-label prescribing involves using an approved drug for a purpose outside its official listing, and is a normal, legal, and common part of medicine when its backed by good evidence

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Statistical analysis was performed with SAS 9.4 software (SAS Institute Inc., Cary, NC, USA), and graphs were made with Microsoft excel for Mac (vers.16.16.27, Microsoft 2018)