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The studies confirmed the GHRH receptor pharmacological profile of the tetrasubstituted scaffold that underpins both variants, with the no-DAC form studied as the pulsatile delivery model and the DAC form providing the prolonged pharmacokinetic extension of that same receptor biology

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doi: 10.1001/jamanetworkopen.2024.57349, 128 SainsburyA.HayP

It is unclear which system or hormone has significance since the ovarian performance is affected by systemic IGF and GH, GH-independent IGF, or GH-induced peripheral IGF

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