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Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullmann D, Tishler PV, and Hennekens CH (1992)

By using this side door into brain cells, leucovorin can restore folate levels in the brain and support normal neuronal functioning despite the antibody interference [3]

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In contrast, the Grooved Pegboard Test, a commonly used measure of fine motor coordination and dexterity, demonstrates a broader dynamic range and has been shown to decline progressively with disease worsening, making it a more reliable response biomarker in longitudinal studies [512]

Clinical trials evaluating the impact of antioxidant-rich diets or supplements on disease incidence, progression, and overall health outcomes will be essential in establishing their efficacy and safety