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Statistical significance was calculated using two-tailed Students t-test, paired or unpaired depending on the manner of acquisition, for experiments with two variables, or by one-way analysis of variance (ANOVA) for experiments with three or more variables, with comparison to a single condition or across conditions depending on the nature of parameters measured, with either Dunnetts or idks post-hoc tests as indicated in the figure legends

Mod GRF 1-29 Modified GRF 1-29 is a synthetic analog of growth hormone releasing hormone (GHRH)

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Aging (Albany NY) (2010) 2:183

Study limitations include presence of statistical heterogeneity in the meta-analyses for change in HbA 1c and body weight, assessment of risk of bias solely for the primary outcome, and generalisation of findings mainly to individuals who are overweight or obese and already on metformin-based background therapy