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Elevation of HDAC11 is observed in patients with hippocampal sclerosis (HS) which are positively related to the down-regulation of IL-10 in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) patients [116]

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They found that in addition to slowing the progression of degeneration in the treatment group compared to controls, the peptide also improved levels of the protein aggrecan