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Anaphylaxis following a B12 injection has been documented in medical literature, particularly in patients with a sensitivity to cobalt or cobalamin compounds

It plays a role wherever purity is critical

Sold through unregulated channels, it lacks safety data, quality control, and proven efficacy

Vitamin B12 (cyanocobalamin or methylcobalamin ) is light-sensitive and can degrade when exposed to UV or fluorescent light

2 Tramadol, a synthetic opioid receptor agonist with properties similar to those of SNRIs, inhibits the reuptake of biogenic aminesincluding serotonin and norepinephrine (similar to SNRI antidepressants)and acts as a weak agonist at the mu-opioid receptor