J Diabetes Res 2018:1232583 Ikonomidis I, Pavlidis G, Thymis J, Birba D, Kalogeris A, Kousathana F, Kountouri A, Balampanis K, Parissis J, Andreadou I, Katogiannis K, Dimitriadis G, Bamias A, Iliodromitis E, Lambadiari V (2020) Effects of glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 inhibitors, and their combination on endothelial glycocalyx, arterial function, and myocardial work index in patients with type 2 diabetes mellitus after 12-month treatment
doi: 10.3390/biology10010034 307 SemenzaG
Its amino acid seque nce is Gly-Glu-Pro-Pro-Pro- Gly-Lys-Pro-Ala-Asp-Asp-Ala- Gly-Leu-Val
In general it is well tolerated , but it can cause nausea, diarrhoea or a characteristic body odour
Spironolactone is a potassium-sparing diuretic used for hypertension and fluid retention, while semaglutide is a GLP-1 receptor agonist for weight loss and diabetes management