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5e, f and Supplementary Movie S3), while no significant changes were detected upon saline injection (Supplementary Fig

The studys methodology and findings revealed data points: Among 710 type 2 diabetes patients, 17 semaglutide users developed NAION versus only 6 non-users, despite similar baseline characteristics In the weight loss cohort of 979 patients, NAION occurred in 20 semaglutide users compared to 3 in the control group Cumulative NAION incidence over 36 months reached 8.9% for diabetic semaglutide users versus 1.8% for non-GLP-1 medications Weight loss patients showed 6.7% NAION incidence with semaglutide versus 0.8% without Manual chart review by neuro-ophthalmology specialists ensured diagnostic accuracy often lacking in larger database studies Risk persisted after controlling for known NAION risk factors including age, sex, hypertension, and sleep apnea The biological plausibility of semaglutide-induced NAION stems from multiple proposed mechanisms that researchers continue investigating

Premature discontinuation of treatment due to adverse effects may also be simply due to the dosage of oral semaglutide and the rate of dose escalation

Because tirzepatide is powerful, it cannot be started at a high dose immediately