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In the STEP 1 trial, semaglutide produced a mean weight reduction of about 14.9% at 68 weeks , with larger absolute reductions in some individuals

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In a phase 2 dose-finding trial, once-weekly Cagrilintide produced clinically meaningful weight loss about 10.8% at the 4.5 mg dose over 26 weeks with gastrointestinal effects the most common adverse events [1]

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