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106 Similarly, lactate levels are significantly higher in senescent microglia of aged and APP/PS1 mice, leading to increased histone Kla, particularly H3K18la

30 , 14251432 (2011) Lazarevic, V

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Indeed, knocking out all three urocortins does not have any major effect on basal corticosterone levels (62) although female urocortin 2 knockout mice exhibit a more subtle dysregulation with elevated basal ACTH and corticosterone secretion which is modulated by their estrogen status (63)

Seventeen (17) out of 18 treated subjects completed the study as per protocol