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Multiple meta-analyses have shown that creatine supplementation during resistance training augments lean tissue mass by 0.9-1.3 kg compared to placebo and this effect is seen even more prominently in older adults and in people engaged in calorie-restricted protocols

Studies have shown that activation of the Wnt pathway is associated with the development of ACM ( 2.3.2 NLRP3 inflammasome pathway The NLRP3 inflammasome is a critical component of the immune response, capable of detecting intracellular pathogens and damage signals ( 2.3.3 Nrf2 pathway ACM is a pathological condition characterized by alterations in atrial structure and function, frequently associated with AF and heart failure (HF) ( 2.3.4 Key molecules and their roles Several key molecules play important roles in the cellular and molecular mechanisms of ACM that affect atrial structure and function

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