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Although proteomic changes induced by GLP-1GIPLani were less robust in the hypothalamus relative to hindbrain, GLP-1GIPLani more robustly induced POMC neuronal activity compared with GLP-1GIP, as assessed in vivo using fibre-photometric assessment of POMC neuronal activity in Pomc-cre mice, and ex vivo using whole-cell patch recordings in Pomc -GFP mice (Fig

The SUSTAIN and SCALE trials showed weight regain trajectories

PMID 9680481

However, the GPI-anchoring module allows the GST fusion to express in the endoplasmic reticulum (ER) lumen and translocate to the out leaflet of the cell membrane through the Golgi apparatus (Kinoshita, 2020), making GST free from the endogenous GSH ligands

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