A role of oxidative stress in GO is supported by a number of basic studies suggesting that ROS promote the proliferation of OFs and the release of GAGs, the synthesis and secretion of cytokines, and the expression of other factors involved in the pathogenesis of GO, namely heat shock protein 72 (HSP-72), HLA-DR and ICAM-1 ( Figure 1 In this context, a number of studies, performed both in vitro and in vivo , investigated the effects of antioxidant agents in GO, including selenium, pentoxifylline, quercetin, enalapril, vitamin C, N-acetyl-L-cysteine and melatonin ( Oxidative Stress and Proliferation of Orbital Fibroblasts Burch et al
And, I mean, I think we're going to see, I hope we're going to see, a lot more functional MRI type studies where people say, "Yeah, yeah, yeah
Potential Benefits (Reported in Literature) May support cellular energy production and mitochondrial function through replenishment of NAD+ pools [1] [8]
Some intestinal diseases, such as inflammatory bowel disease (IBD) or irritable bowel syndrome, can change the composition of the intestinal microbiota and affect the homeostasis of the intestinal carnitine pool
I dont want studies
