TB-500 (or rather its parent Tb4) has high-profile cardiac and corneal repair publications in Nature and JID , but the synthetic LKKTETQ fragment specifically has thinner independent literature than the full-length protein
13b, Supplementary Table 9), indicating that the interactions between the C-terminal tyrosine and RAMP3 can compensate, in this peptide context, the reduced CTR ECD affinity derived from the P37Y substitution
DoW SBIR/STTR Components are now also required to notify SBCs of denial determinations, a new transparency obligation intended to give companies actionable feedback
The peptide reduces production of pro-inflammatory cytokines including IL-1, TNF-, and IL-6 while enhancing expression of anti-inflammatory mediators such as IL-10 and TGF-, creating a cytokine milieu that supports tissue repair rather than ongoing damage
Athira Pharma (formerly M3 Biotechnology), the WSU spinout founded to commercialize Dihexa-derivative compounds, paid approximately $4 million in a False Claims Act settlement in January 2025 after a whistleblower exposed concealment of the research misconduct from federal grant agencies, and approximately $10 million in a separate class-action settlement to investors
