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Its purpose is not to discourage innovation, but to channel it toward molecules whose biology permits success

Non-adherence to medication regimens in individuals with depression who develop diabetes may contribute to the increased observed risk of complications such as cardiovascular disease, neuropathy, and retinopathy [139]

Patients may wish to be examined to determine whether they are susceptible to angle closure, and have a prophylactic procedure (e.g., iridectomy), if they are susceptible

Maintaining appropriate hydration helps prevent dehydration-related headaches and may also reduce the severity of nausea

DRUG INTERACTIONS As with other medications, zonisamide can interact with certain medications, including carbonic anhydrase inhibitors (such as acetazolamide), orlistat (if using zonisamide for a seizure disorder), phenobarbital, primidone, rifamycins, glucocorticoids, and St