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The membrane was blocked with 5% skim milk for 1 h at room temperature and incubated with primary antibodies Bax, Bcl-2, Keap1, Nrf2, ZO-1, E-cadherin (1:1000 dilution) overnight at 4 , followed by HRP-conjugated secondary antibodies for additional 1 h at 37

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I remain committed to delivering sustainable shareholder value through robust cash returns, with progressive dividends and sustainable share buy-backs, including 1.3 billion programme for 2026. EXHIBIT 1 1 Revenue by Region (bn) YoY movements at constant rates -7% +6% +3% Change in Profit from Operations: Reported +265 % APFO1,3 at CC2 +2.3 % Change in Group Revenue: Reported -1.0 % At CC2 +2.1 % 1