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Patients who transition from gastric banding to other bariatric procedures such as sleeve gastrectomy or Roux-en-Y gastric bypass should be aware that these carry a higher risk of B12 and other micronutrient deficiencies due to their malabsorptive components, and monitoring should be intensified accordingly

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The honest answer is that the human safety data is limited compared to decades-old pharmaceuticals, but the preclinical safety record across multiple species is unusually clean for a peptide with this level of biological activity

Very rarely, thyroid patients can have their thyroid gland completely removed and still not need thyroid medication