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Pyruvate kinase-mediated (PKM) PEP-to-pyruvate conversion reveals dual metabolic fate: pyruvate dehydrogenase (PDH)-dependent acetyl-CoA production for TCA cycle entry versus lactate dehydrogenase (LDH)-driven lactate (LA) generation, epitomizing the Warburg phenotype

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Or perhaps magnesium works well for two weeks and then seems to lose effectiveness, suggesting you need to adjust the dose or try a different form