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Semaglutide is a long-acting GLP-1 receptor analog featuring an Aib substitution at position 2 to confer DPP-IV resistance and a fatty-acid (C18 diacid) side chain at Lys26 that promotes albumin binding for extended plasma residence

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Its status as a research-only chemical automatically places it on the prohibited list

Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimers disease neurons