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Both medications are glucagon-like peptide-1 (GLP-1) receptor agonists, though tirzepatide also activates GIP receptors, which may contribute to slightly stronger average weight loss results in clinical trials

Without nutritional guidance, patients may inadvertently develop nutrient deficiencies, lose muscle mass due to inadequate protein intake, or fail to establish the eating patterns needed for long-term weight maintenance

Other GLP-1/GIP/GCG Triple Agonists in Development Besides retatrutide, several GLP-1/GIP/GCG triple agonists are in early-stage clinical trials (Table 3), though the WL efficacy associated with these medications remains unknown

However, weight loss distribution varies based on genetics, age, and lifestyle factors

Improved insulin sensitivity also helps your body use energy more efficiently