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Research shows the risk increases after 6+ months of therapy, particularly in those with plant-based diets or existing digestive conditions

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This FDA-approved therapy helps reduce pain, improve mobility, and delay or potentially avoid the need for knee replacement surgery in patients with osteoarthritis [1]

Fasted-state dosing eliminates dietary nicotinamide competition for NNMT binding sites, increasing effective dose by 3542% compared to post-meal administration

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