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Additional studies in cynomolgus monkeys have confirmed the potent dose-dependent, weight-lowering effects of chronic GLP-1R/GcgR co-agonism [78], supporting the translational promise of this novel balanced agonism for obesity and type 2 diabetes

So, these medications are usually started at a very low dose to get your body used to it

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Another frequent misconception is that higher doses always work better. Your body can only process so much material at once