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It is also advised to avoid mega doses of pyridoxine in pregnant or breastfeeding patients unless necessary, since safety data for doses beyond the recommended dietary allowance are limited

However, current retail pricing at Canadian pharmacies remains within the documented $300-570 range for most patients

doi: 10.1002/fsn3.2407 222

The needle is then secured in place with a piece of tape or bandage, and the IV drip is started

Efficiacy results were analysed based on the reported efficacy estimand (calculated from data gathered while patients received their assigned randomized treatment, excluding data after discontinuing the allotted medication or after adding rescue medication