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Trimetazidine is lipophilic and crosses the blood-brain-barrier [112], hence it is highly likely to exert anti-inflammatory effects also in the brain

This article covers the science: how BPC-157 works, what the research shows, and how clinicians reason about using it

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It has been traditionally thought that exogenous GABA (i.e., taken as a supplement) does not cross the bloodbrain barrier, but data obtained from more recent research (2010s) in rats describes the notion as being unclear