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The peptide approach targets collagen synthesis thickening dermis to obscure vasculature and circulation improvement reducing blood stagnation creating visible discoloration

Springer International Publishing, Cham, Switzerland Wilkening S, Stahl F, Bader A (2003) Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

Polymorphisms in HLA class II DR3 predispose to GD, while for HT various HLA alleles have been reported such as DR3, DR5, DQ7, DQB1, DQw7, and others

Because of incongruent phases of development and heterogeneous study designs, it is impossible to compare efficacy, safety, and tolerability between the reported agents

[PMC free article: PMC4848993] [PubMed: 27070596] (Listing of published cases of liver injury from HDS products including 11 reports describing a total of 57 cases attributed to Herbalife products published between 2004 and 2015)