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Hsu TM, Hahn JD, Konanur VR, Lam A, Kanoski SE

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Rotating injection sites within the same body area reduces localized irritation and lipohypertrophy

[200] [199] Depending on the protein kinase involved and the residue(s) phosphorylated, phosphorylation can shift transporter function into an efflux-permissive state that causes the reverse transport of cytosolic monoamines into the synaptic cleft, or it can promote transporter internalization, whereby phosphorylated transporters are withdrawn from the plasma membrane and lower total reuptake capacity (i.e., non-competitive reuptake inhibition)

The overall discontinuation rate due to adverse events is lower with semaglutide than with phentermine