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Molecules that show promise in terms of biological activity may still exhibit poor pharmacokinetic profiles, thus reducing their overall therapeutic potential

Residual OCTN2 transporter activity, carnitine levels and symptoms correlate in patients with primary carnitine deficiency

Typically, outpatient clinic appointments for buprenorphine/naloxone induction require hours of provider time and can be difficult to schedule, resulting in protracted wait times

Patients should understand that off-label microdosing lacks the evidence base that supports FDA-approved dosing, and outcomes may differ significantly from those observed in clinical trials

Selkoe DJ