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Arsenic upregulates interleukin (IL)-1, IL-8, granulocyte macrophage colony-stimulating factor, transforming growth factor-, tumor necrosis factor-, and keratin8, 16, and 18 and decreases the expression of transcription factors activator protein AP-1 and AP-2, loricrin, filaggrin, small proline-rich (spr) protein1, and keratin 10

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Another reason electronic cigarettes and the vape industry, in general, are considered high risk is due to health and safety concerns with vape products

Thirdhand smoke can be, too Thirdhand smoke: What is it and what are its risks