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The autophagy adaptor p62/SQSTM1, essential for targeting ubiquitinated substrates to autophagosomes, is mutated in ALS and FTD, where impaired p62 function results in aggregation-prone protein accumulation and neuronal toxicity

doi: 10.1016/j.neuropharm.2016.12.010 71 CogramPDeaconRMJWarner-SchmidtJLvon SchimmelmannMJAbrahamsBSDuringMJ

SS-31 (Elamipretide) SS-31 is a mitochondrial-targeting peptide that binds to cardiolipin , a key lipid in mitochondrial membranes

Funciona facilitando el transporte de cidos grasos a las mitocondrias para su oxidacin y produccin de energa

Dose escalation phase (months 1 to 4) Each dose increase temporarily reintroduces GI side effects as your body adjusts to the higher level