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History of acute pancreatitis Baseline characteristics Age - 55.85 yr Female sex - 57.1% Average body weight - 210 lbs (96 kg) Average BMI - 34.65 Type 2 diabetes - 55.9% Average ALT - 67.85 U/liter Average AST - 53.0 U/liter Fibrosis stage 2 - 31.3% Fibrosis stage 3 - 68.8% Randomized treatment groups Group 1 (534 patients): Semaglutide with a target dose of 2.4 mg once weekly Group 2 (266 patients): Placebo The starting dose of semaglutide was 0.25 mg once weekly, which was increased every 4 weeks to once-weekly doses of 0.5 mg, 1.0 mg, 1.7 mg, and 2.4 mg until the target dose of 2.4 mg was reached after the 16-week dose-escalation period

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Osteogenic growth peptide (OGP) Studies have found that the naturally-occurring osteogenic growth peptide can increase bone formation and overall bone mass [5]

A firm lump at the injection site that persists beyond 48 hours is likely lipohypertrophy fibrous tissue buildup from repeated injections in the same location

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