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For this group, tirzepatide's GIP pathway represents a genuine alternative route

In women with PCOS, these mechanisms lead to: Reduced fasting insulin levels Improved insulin sensitivity at the cellular level Lower circulating insulin, which in turn lowers ovarian androgen production (insulin promotes androgen production in the ovaries) As insulin sensitivity improves, blood sugar levels stabilize, which is essential for managing PCOS-related symptoms

In other words, if you have not experienced significant GI side effects by week 20, you are unlikely to develop them going forward on a stable dose

Retrieved from Kolb, H., Martin, S., & Kempf, K

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