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However, doses of bisphenol-A higher than 100 M induce a substantial reduction the viability and the number of proliferating NSPCs in neurospheres, as well as the number of neurons and astroglial cells derived from them (Tiwari et al., 2015b)

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Inhibition of CYP450 isoforms may result in adverse effects such as an increased risk of toxicity, drugdrug interactions, potential complications in future clinical trials, and regulatory challenges

However, due to the severe side effects, these drugs are not considered the first choice for treating depression

As of late 2021, available evidence suggests first-line therapy with SGLT2 inhibitors may improve some outcomes, particularly in individuals with newly diagnosed diabetes and comorbid heart and kidney health concerns