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Pharmacology and characteristics of the device The efficacy and safety demonstrated by liraglutide were the basis for the development of semaglutide

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In a phase 2 trial, survodutide, an injectable dual glucagon/GLP-1 receptor agonist, produced significant mean weight losses: 6.2%, 12.5%, 13.2%, and 14.9% at 0.6 mg, 2.4 mg, 3.6 mg, and 4.8 mg, respectively, compared to 2.8% in the placebo group [96]

They improved glucose tolerance and reduced glycated hemoglobin (HbA1c) and fructosamine levels in mice (143, 144)