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Peripheral Metabolic and Systemic Effects Beyond the pancreas and brain, GLP-1 RAs exert beneficial effects on peripheral tissues that aid in treating metabolic dysfunction

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Individuals who are pregnant or breastfeeding, have certain medical conditions, or have a history of adverse reactions to weight loss medications may not qualify

Hexosamine pathway overactivation Alters gene expression (e.g., PAI-1 and TGF-) promoting microvascular ischemia, oxidative stress, and neuronal apoptosis (78)