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In a Phase 2 clinical trial published in 2023 in the New England Journal of Medicine (Jastreboff et al.), participants receiving the highest dose of retatrutide lost up to approximately 24% of their body weight over 48 weeks a notably greater reduction than observed with currently approved agents

If possible, multicenter clinical trials should be conducted in as many regions as possible

Cardiometabolic Research Beyond weight reduction, retatrutide's glucagon receptor component has attracted research interest for its cardiovascular effects

And examples would be New Jersey, Maryland, Illinois, Pennsylvania, Ohio